/* ===== RESET & BASE ===== */
  *, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
  html { font-size: 15px; scroll-behavior: smooth; }
  body {
    font-family: Georgia, 'Times New Roman', Times, serif;
    background: #f4f2ee;
    color: #1a1a1a;
    line-height: 1.65;
  }

  /* ===== STICKY HEADER ===== */
  #sticky-header {
    position: sticky; top: 0; z-index: 100;
    background: #0a1628;
    border-bottom: 3px solid #c9a227;
    padding: 8px 24px;
    display: flex; align-items: center; justify-content: space-between;
    box-shadow: 0 2px 12px rgba(0,0,0,0.35);
  }
  #sticky-header .journal-name {
    font-family: 'Helvetica Neue', Arial, sans-serif;
    font-size: 0.78rem; font-weight: 700; letter-spacing: 0.12em;
    color: #c9a227; text-transform: uppercase;
  }
  #sticky-header .article-short-title {
    font-family: Georgia, serif; font-size: 0.72rem;
    color: #c8d8e8; font-style: italic; max-width: 60%;
    white-space: nowrap; overflow: hidden; text-overflow: ellipsis;
  }
  #sticky-header .open-access-badge {
    background: #1a7a8a; color: #fff;
    font-family: Arial, sans-serif; font-size: 0.65rem; font-weight: 700;
    padding: 3px 9px; border-radius: 12px; letter-spacing: 0.08em;
    text-transform: uppercase;
  }

  /* ===== PAGE WRAPPER ===== */
  .page-wrapper {
    max-width: 1100px; margin: 0 auto;
    background: #fff;
    box-shadow: 0 0 40px rgba(0,0,0,0.12);
  }

  /* ===== JOURNAL MASTHEAD ===== */
  .masthead {
    background: #0a1628;
    padding: 28px 48px 20px;
    border-bottom: 4px solid #c9a227;
  }
  .masthead-top {
    display: flex; align-items: center; justify-content: space-between;
    margin-bottom: 10px;
  }
  .journal-logo-area {
    display: flex; flex-direction: column;
  }
  .journal-full-name {
    font-family: 'Helvetica Neue', Arial, sans-serif;
    font-size: 1.22rem; font-weight: 800; letter-spacing: 0.06em;
    color: #c9a227; text-transform: uppercase;
  }
  .journal-subtitle {
    font-family: Arial, sans-serif; font-size: 0.72rem;
    color: #8aa8c8; letter-spacing: 0.14em; text-transform: uppercase;
    margin-top: 2px;
  }
  .masthead-badges {
    display: flex; gap: 8px; align-items: center;
  }
  .badge {
    font-family: Arial, sans-serif; font-size: 0.63rem; font-weight: 700;
    padding: 4px 11px; border-radius: 14px; letter-spacing: 0.07em;
    text-transform: uppercase;
  }
  .badge-oa { background: #1a7a8a; color: #fff; }
  .badge-peer { background: #2d6a2d; color: #fff; }
  .badge-theory { background: #8a3a00; color: #fff; }

  .masthead-meta {
    display: flex; gap: 28px; flex-wrap: wrap;
    border-top: 1px solid #1e3a5a;
    padding-top: 10px; margin-top: 4px;
  }
  .masthead-meta span {
    font-family: Arial, sans-serif; font-size: 0.68rem; color: #8aa8c8;
    letter-spacing: 0.04em;
  }
  .masthead-meta span strong { color: #c9a227; }

  /* ===== TOP VISUAL BANNER ===== */
  .top-visual {
    margin: 0;
    background: #07101d;
    border-top: 1px solid #1e3a5a;
    border-bottom: 1px solid #c9a227;
    padding: 14px;
  }
  .top-visual img {
    display: block;
    width: 100%;
    max-width: 1020px;
    margin: 0 auto;
    height: auto;
    border-radius: 8px;
    border: 1px solid rgba(201,162,39,0.5);
    box-shadow: 0 8px 28px rgba(0,0,0,0.35);
  }

  /* ===== ARTICLE HEADER ===== */
  .article-header {
    padding: 36px 48px 24px;
    border-bottom: 1px solid #ddd;
    background: #fff;
  }
  .article-type-label {
    font-family: Arial, sans-serif; font-size: 0.7rem; font-weight: 700;
    color: #1a7a8a; text-transform: uppercase; letter-spacing: 0.13em;
    margin-bottom: 14px;
  }
  .article-main-title {
    font-family: Georgia, serif; font-size: 1.85rem; font-weight: 700;
    line-height: 1.28; color: #0a1628; margin-bottom: 18px;
  }
  .article-main-title em { font-style: italic; }
  .authors-line {
    font-family: Arial, sans-serif; font-size: 0.88rem; color: #444;
    margin-bottom: 8px;
  }
  .authors-line a { color: #1a7a8a; text-decoration: none; }
  .affiliation {
    font-family: Arial, sans-serif; font-size: 0.76rem; color: #666;
    font-style: italic; margin-bottom: 6px;
  }
  .corresponding-badge {
    display: inline-block;
    background: #fff3cd; border: 1px solid #c9a227;
    color: #6b4e00; font-family: Arial, sans-serif;
    font-size: 0.7rem; padding: 4px 12px; border-radius: 4px;
    margin-top: 6px;
  }
  .article-dates {
    display: flex; gap: 24px; margin-top: 14px; flex-wrap: wrap;
  }
  .article-dates span {
    font-family: Arial, sans-serif; font-size: 0.72rem; color: #888;
  }
  .article-dates span strong { color: #555; }

  /* ===== REVOLUTIONARY CALLOUT ===== */
  .revolutionary-callout {
    margin: 0 48px 0;
    background: linear-gradient(135deg, #0a1628 0%, #1a3a5c 100%);
    border-left: 5px solid #c9a227;
    padding: 16px 24px;
    border-radius: 0 6px 6px 0;
  }
  .revolutionary-callout .rev-label {
    font-family: Arial, sans-serif; font-size: 0.65rem; font-weight: 800;
    color: #c9a227; text-transform: uppercase; letter-spacing: 0.15em;
    margin-bottom: 6px;
  }
  .revolutionary-callout p {
    font-family: Arial, sans-serif; font-size: 0.82rem; color: #d8e8f4;
    line-height: 1.55;
  }

  /* ===== ABSTRACT ===== */
  .abstract-section {
    margin: 24px 48px;
    background: #f0f6fa;
    border: 1px solid #b8d4e8;
    border-radius: 6px;
    padding: 24px 28px;
  }
  .abstract-title {
    font-family: 'Helvetica Neue', Arial, sans-serif;
    font-size: 0.78rem; font-weight: 800; letter-spacing: 0.12em;
    text-transform: uppercase; color: #0a1628;
    border-bottom: 2px solid #0a1628; padding-bottom: 6px;
    margin-bottom: 16px;
  }
  .abstract-block { margin-bottom: 10px; }
  .abstract-block strong {
    font-family: Arial, sans-serif; font-size: 0.8rem;
    color: #1a7a8a; text-transform: uppercase; letter-spacing: 0.06em;
  }
  .abstract-block p {
    font-size: 0.88rem; color: #333; margin-top: 2px;
  }
  .keywords-line {
    margin-top: 16px; padding-top: 12px;
    border-top: 1px solid #cce0f0;
    font-family: Arial, sans-serif; font-size: 0.76rem; color: #555;
  }
  .keywords-line strong { color: #0a1628; }
  .kw { color: #1a7a8a; }

  /* ===== TWO-COLUMN BODY ===== */
  .article-body {
    padding: 32px 48px;
    columns: 2; column-gap: 36px;
    column-rule: 1px solid #e0e0e0;
  }
  /* Figures and tables span both columns */
  .full-width {
    column-span: all;
    break-inside: avoid;
  }

  /* ===== SECTION HEADINGS ===== */
  .section-heading {
    font-family: 'Helvetica Neue', Arial, sans-serif;
    font-size: 1.05rem; font-weight: 800;
    color: #0a1628; margin: 28px 0 10px;
    border-bottom: 2px solid #c9a227;
    padding-bottom: 4px; letter-spacing: 0.03em;
    break-after: avoid;
  }
  .section-heading .sec-num {
    color: #c9a227; margin-right: 4px;
  }
  .subsection-heading {
    font-family: 'Helvetica Neue', Arial, sans-serif;
    font-size: 0.92rem; font-weight: 700;
    color: #1a3a5c; margin: 18px 0 7px;
    break-after: avoid;
  }
  .subsection-heading .sub-label {
    background: #1a7a8a; color: #fff;
    font-size: 0.7rem; padding: 2px 8px;
    border-radius: 3px; margin-right: 8px;
    vertical-align: middle;
  }

  /* ===== BODY TEXT ===== */
  p { margin-bottom: 10px; font-size: 0.9rem; text-align: justify; }
  gene, .gene { font-family: 'Courier New', Courier, monospace; font-size: 0.85em; color: #0a1628; background: #eef4ff; padding: 1px 4px; border-radius: 3px; }

  /* ===== CALLOUT BOXES ===== */
  .info-box {
    background: #fff8e6; border: 1px solid #c9a227;
    border-left: 4px solid #c9a227;
    border-radius: 4px; padding: 14px 16px; margin: 14px 0;
    break-inside: avoid;
  }
  .info-box .box-title {
    font-family: Arial, sans-serif; font-size: 0.75rem; font-weight: 800;
    text-transform: uppercase; color: #8a5c00; letter-spacing: 0.1em;
    margin-bottom: 6px;
  }
  .info-box p { font-size: 0.84rem; color: #4a3800; margin-bottom: 4px; }

  .theory-box {
    background: #f0fafa; border: 2px solid #1a7a8a;
    border-radius: 6px; padding: 16px 18px; margin: 16px 0;
    break-inside: avoid;
  }
  .theory-box .box-title {
    font-family: Arial, sans-serif; font-size: 0.75rem; font-weight: 800;
    text-transform: uppercase; color: #0a5060; letter-spacing: 0.1em;
    margin-bottom: 8px;
  }
  .theory-box p { font-size: 0.84rem; color: #0a3040; margin-bottom: 4px; }

  /* ===== FIGURES ===== */
  .figure-block {
    break-inside: avoid;
    margin: 22px 0;
    text-align: center;
  }
  .figure-block svg { max-width: 100%; height: auto; }
  .fig-caption {
    font-family: Arial, sans-serif; font-size: 0.76rem;
    font-style: italic; color: #555;
    margin-top: 8px; text-align: left;
    line-height: 1.45;
  }
  .fig-caption strong {
    font-style: normal; color: #0a1628;
    font-weight: 700;
  }

  /* ===== TABLES ===== */
  .table-wrapper {
    overflow-x: auto; margin: 20px 0;
    break-inside: avoid;
  }
  table {
    width: 100%; border-collapse: collapse;
    font-family: Arial, sans-serif; font-size: 0.78rem;
  }
  table caption {
    font-style: italic; color: #555; font-size: 0.76rem;
    text-align: left; margin-bottom: 6px; caption-side: top;
  }
  table caption strong { font-style: normal; color: #0a1628; }
  thead tr { background: #0a1628; color: #fff; }
  thead th {
    padding: 9px 12px; font-weight: 700;
    text-align: left; letter-spacing: 0.04em;
    border: 1px solid #1e3a5a;
  }
  tbody tr { border-bottom: 1px solid #dde8f0; }
  tbody tr:nth-child(even) { background: #f5f9fc; }
  tbody td { padding: 8px 12px; vertical-align: top; }
  .nset-row { background: #fff3cd !important; font-weight: 700; }
  .nset-row td { color: #4a3000; }
  .check { color: #1a7a8a; font-weight: 700; }
  .cross { color: #c04000; font-weight: 700; }

  /* ===== REFERENCES ===== */
  .references-list {
    list-style: none; padding: 0;
    counter-reset: ref-counter;
  }
  .references-list li {
    counter-increment: ref-counter;
    font-size: 0.8rem; color: #444;
    padding: 5px 0 5px 28px; position: relative;
    border-bottom: 1px dotted #ddd;
    break-inside: avoid;
  }
  .references-list li::before {
    content: counter(ref-counter) ".";
    position: absolute; left: 0;
    color: #1a7a8a; font-weight: 700;
  }
  .references-list li em { color: #0a1628; }
  .doi-link { color: #1a7a8a; word-break: break-all; }

  /* ===== FOOTER ===== */
  .article-footer {
    background: #0a1628;
    color: #8aa8c8; padding: 22px 48px;
    border-top: 3px solid #c9a227;
    font-family: Arial, sans-serif; font-size: 0.75rem;
    display: flex; align-items: center; justify-content: space-between;
    flex-wrap: wrap; gap: 8px;
  }
  .article-footer a { color: #c9a227; text-decoration: none; }
  .footer-copyright { color: #5a7a9a; }

  /* ===== PROTOCOL TABLE ===== */
  .protocol-table thead tr { background: #1a3a5c; }
  .protocol-step { background: #eef4fa; font-weight: 700; color: #0a1628; }

  /* ===== PRINT ===== */
  @media print {
    #sticky-header { display: none; }
    .page-wrapper { box-shadow: none; max-width: 100%; }
    body { background: #fff; }
    .article-body { columns: 2; }
  }

  /* ===== RESPONSIVE ===== */
  @media (max-width: 768px) {
    .article-body { columns: 1; }
    .masthead { padding: 18px 20px; }
    .article-header { padding: 22px 20px; }
    .revolutionary-callout { margin: 0 20px; }
    .abstract-section { margin: 16px 20px; }
    .article-body { padding: 20px 20px; }
    .article-footer { padding: 16px 20px; }
  }